Resources & Links:
Public Health and Toxicology Information
Agency for Toxic Substances and Diseases Registry (ATSDR)
ATSDR provides health information to prevent harmful exposures and diseases related to toxic substances. ToxFAQs are summaries about hazardous substances, which include information about exposure to hazardous substances found in hazardous waste sites (and elsewhere) and related health effects. It also provides toxicological profiles on these substances.
Agency of Toxic Substances & Disease Registry (ATSDR), Toxic Substances Portal Toxicological Profiles
From CERCLA, ATSDR worked with USEPA to develop a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) and prepare toxicological profiles for each substance included on the priority list of hazardous substances. The toxicological profiles include an examination, summary, and interpretation of available toxicological information and epidemiologic evaluations of a hazardous substance. During the development of toxicological profiles, MRLs are derived when ATSDR determines that reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure to the substance.
California Air Resources Board (CARB), Toxic Air Contaminant (TAC) Identification List
The TAC Identification List is composed of substances that have been identified by the State Board as toxic air contaminants. If there are known threshold exposure levels for any of these contaminants, these have been listed along with any reports from exposure assessments, health effect studies, and public comments.
California Department of Pesticide Regulation, Pesticide Information Databases
The DPR has a number of collections of data and other information related to pesticide registration, licensing, pesticide use, environmental effects, enforcement, and other elements of the program. Major online databases and datasets are listed, some of which can be queried and searched directly. Others can be downloaded and the data manipulated with database or spreadsheet software.
California Department of Pesticide Regulation (DPR), Pesticide Data Index Database
DPR’s library of pesticide data includes more than 76,000 volumes of data containing more than 210,000 studies. Pesticide studies submitted to DPR have been indexed into a database using several different criteria. It provides information about all products containing the pesticide, including a subsection for just the active products.
California Department of Pesticide Regulation, Product/Label Database
DPR’s Product/Label Database contains information concerning all pesticide products registered in California. It includes registrant name and address, chemical ingredients, product names, site/pest category uses, pesticidal type, formulation code, registration status, dates, and other types of information.
California Department of Pesticide Regulation, New California Product Registrations
The New California Product Registrations is a search engine that lists pesticide products registered in California the past 12 months.
California Department of Toxic Substances Control (DTSC), Chemical Information Tool (CIT)
This link provides access to DTSC's Chemical Information Tool. Users can search for chemicals and associated hazard traits and end points. The chemical search searches by chemical name or CASRN number. The advanced search is intended for searching by hazard trait or end point although it will search the authoritative sources by any key words.
California Proposition 65 Chemical List
California’s OEHHA publishes and updates the Prop 65 list of chemicals known to the state to cause cancer or developmental/reproductive toxicity. It adopts safe harbor levels for the chemicals and provides guidance for calculating a level in the absence of this safe harbor level. Businesses that cause exposures greater than the safe harbor level must notify customers and/or consumers with Prop 65 warnings.
California Office of Environmental Health Hazard Assessment (OEHHA), Toxicity Criteria Database
The OEHHA Toxicity Criteria Database contains a variety of chemicals and includes information on the uses, reference exposure levels, CA public health goals, Prop 65 levels, and cancer potency.
Carcinogenic Potency Database (CPDB)
The CPDB is an international resource that includes results of 6540 chronic, long-term animal cancer tests for 1547 chemicals. The CPDB provides access to bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
Chemical Carcinogenesis Research Information System (CCRIS)
CCRIS is a toxicology data file that contains carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results for over 9,000 chemicals. It is a scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). Data are derived from studies cited in primary journals, current awareness tools, NCI reports, and other special sources.
Chemical Identifier Resolver (beta)
The Chemical Identifier Resolver works as a resolver for different chemical structure identifiers and allows one to convert a given structure identifier into another representation or structure identifier. It can help you identify and find the chemical structure if you have an identifier such as an InChIKey. It's still in beta testing.
Comparative Toxicogenomics Database (CTD)
CTD promotes understanding about the effects of environmental chemicals on human health by integrating data from curated scientific literature to describe chemical interactions with genes and proteins, and associations between diseases and chemicals, and diseases and genes/proteins. CTD is working to enhance the capacity to identify environment–disease connections by developing an Exposure Ontology (ExO) that will be used to curate and present exposure data.
Chemical Risk Information Platform (CHRIP)
CHRIP is a database provided free of charge and managed by the Japanese National Institute and Technology and Evaluation. It provides comprehensive information on risk assessments (including toxicity, hazards, chemical/physical properties, exposures, etc.) and Japanese and international laws and regulations of chemical substances. It also includes information on biodegradation and bioconcentration of existing chemical substances. These substances can be searched by entering the number or name, by category lists, or by structure.
Data Bank of Environmental Properties of Chemicals (EnviChem)
The EnviChem database consists of toxicity information on substances in relation to different species, especially aquatic organisms, together with information on the persistence and accumulation of these substances in the environment. The information is mainly compiled from scientific literature, handbooks and databases in the field of ecotoxicology. The database also contains practical data on chemical substances for that purpose.
Developmental and Reproductive Toxicology/Environmental Teratology Information Center (DART/ETIC)
DART/ETIC is a bibliographic database that covers. It covers teratology and other aspects of developmental and reproductive toxicology. It contains over 200,000 references to literature published since 1965.
European Bioinformatics Institute (EBI), Chemical Entities of Biological Interest (ChEBI)
ChEBI is a database of molecular entities focused on small chemical compounds. These molecular entities can be either products of nature or synthetic products used to intervene in the processes of living organisms. It also includes classification, nomenclature, and ontology. A number of other sources, such as ChEMBL, PDBeChem, and KEGG COMPOUND are accessible through ChEBI.
European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL), ChEMBL
ChEMBL is a database of bioactive drug-like small molecules focusing on chemical properties. It contains 2-D structures, calculated properties (e.g. logP, Molecular Weight, Lipinski Parameters, etc.), and abstracted bioactivities (e.g. binding constants, pharmacology and ADMET data).
European Chemicals Agency (ECHA) Information on Chemicals
The ECHA Information on Chemicals section serves as a gateway to ECHA's public databases on chemical substances, which contain a large range of information including chemical/physical properties, environmental impact, uses, toxicological data, etc. It also includes information on registration dossiers for substances where a testing proposal has been made, together with information related to the transitional arrangements from the previous chemicals legislation.
European Chemicals Agency (ECHA), Candidate List of Substances of Very High Concern
The ECHA Candidate List of Substance of Very High Concern contains information on each of the substances that are considered very harmful to human health and/or the environment by ECHA. For each substance, it includes chemical properties and data from hazard assessments, justifying its inclusion on the list.
European Chemicals Agency’s Dissemination Portal
This list serves as the European Chemicals Agency’s Dissemination portal with information on chemical substances registered under REACH. It contains all of the information constantly being submitted to and processed by ECHA due to the deadlines of the REACH regulations.
European Chemical Substances Information System (ESIS)
ESIS is a complex, heterogeneous information system which provides information on chemicals.
European Commission Endocrine Disruptor Program
The EC Endocrine Disruptor Program provides information about the endocrine disruption and the strategies to approaching these chemicals. A priority list of endocrine disruptors with a database of reports and studies regarding these chemicals are also available.
European Respiratory Review (ERR)
The ERR is an open access journal published quarterly by the European Respiratory Society (ERS), providing an update on medicine, science and surgery for respiratory professionals. The ERR contains review articles, editorials and correspondence, in addition to summaries of the most important recent research findings and published studies in topics such as COPD, asthma, pulmonary hypertension, lung cancer and tuberculosis.
Finnish Institute of Occupational Health (FIOH)
FIOH is a research and specialist organization in the field of occupational health and safety. It examines various health and safety hazards and produce tools to improve occupational health and reduce risks.
Globally Harmonized System (GHS)
The GHS is a classification scheme for chemicals to consistently communicate hazard information about chemicals world-wide. The GHS includes harmonized criteria for classifying substances and mixtures according to their health, environmental and physical hazards, as well as harmonized requirements for labeling and safety data communication.
Hazardous Substances Data Bank (HSDB)
HSBD focuses on the toxicology of potentially hazardous chemicals and is enhanced with individual chemical information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, nanomaterials, and related areas. It includes about 5,000 chemicals. All data are peer-reviewed and referenced from a core set of books, government documents, technical reports and selected primary journal literature.
Household Products Database (HPD)
The HPD links over 12,000 consumer brands to health effects from Material Safety Data Sheets (MSDS) provided by manufacturers and allows scientists and consumers to research products based on chemical ingredients. The database is designed to help answer questions such as what chemicals are in certain products, at what concentration are they present, and what are the potential health effects.
Information on Hazardous Chemicals and Occupational Diseases (Haz-Map)
Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the health effects of exposure to chemicals and biologicals at work. Haz-Map links jobs and hazardous tasks with occupational diseases and their symptoms. The main links in Haz-Map are between chemicals and occupational diseases, in which causality has been established based on current scientific evidence.
International Agency for Research on Cancer (IARC)
IARC promotes international collaboration in cancer research and developed criteria to evaluate carcinogenic risks to humans and publishes monographs describing these evaluations. It also maintains a summary list of agents classified by IARC monographs, but recommends consulting the monograph itself for full interpretation of the classification.
International Programme on Chemical Safety (IPCS), Chemical Safety Information from Intergovernmental Organizations (INCHEM)
IPCS INCHEM is an invaluable tool that focuses on safety and the sound management for a wide range of commercial chemicals. It consolidates current, internationally peer-reviewed chemical safety-related publications and database records from international bodies, for public access.
International Toxicity Estimates for Risk (ITER)
ITER is a toxicology data file containing data in support of human health risk assessments. It is compiled by Toxicology Excellence for Risk Assessment (TERA) and contains over 650 chemical records with key data various agencies and peer-reviewed world-wide. ITER provides a comparison of international risk assessment information in a side-by-side format and explains differences in risk values derived by different organizations. ITER data focuses on hazard identification and dose-response assessment.
Japan Existing Chemical Data Base (JECDB)
The JECDB contains a number of toxicity test reports from Japan's existing chemicals safety program. The summary of these reports are in English while the actual toxicity studies are in Japanese.
Medical Subject Headings (MeSH)
MeSH is the NLM’s controlled vocabulary thesaurus for indexing articles from 5,400 of the world's leading biomedical journals for the MEDLINE/PubMED database. It is also used for the NLM-produced database that includes cataloging of books, documents, and audiovisuals acquired by the Library. Each bibliographic reference is associated with a set of MeSH terms that describe the content of the item. Similarly, search queries use MeSH vocabulary to find items on a desired topic.
National Toxicology Program Office of Health Assessment and Translation (OHAT)
The NTP OHAT conducts technical assessments focused on understanding the potential for adverse effects on human health by agents, substances, mixtures, or exposure circumstances. These evaluations can lead to NTP opinions on whether these substances may be of concern given what is known about current human exposure levels. OHAT produces NTP Monographs, state-of-the-science workshop reports, or peer-reviewed journal publications based on their evaluations.
National Toxicology Program Report on Carcinogens (RoC)
The RoC is a congressionally mandated, science-based, public health report that identifies agents, substances, mixtures, or exposures in our environment that may potentially put people in the United States at increased risk for cancer. For every substance listed, the RoC contains a profile including cancer studies (mechanism, human, animal), potential sources of exposure, and current federal regulations to limit exposures.
National Institute for Occupational Safety and Health (NIOSH)
NIOSH focuses on conducting research and making recommendations for the prevention of work-related injury and illness. Especially helpful are the hazards & exposures and chemical-related resources, including NIOSH Pocket Guide to Chemical Hazards and Prevention through Design (PTD) materials. It also provides information on various other occupational health issues and topics.
New Jersey Right to Know Hazardous Substance Fact Sheets
The Hazardous Substance Fact Sheets are prepared on pure substances and contain information on health hazards, exposure limits, personal protective equipment, proper handling, first aid, and emergency procedures for fires and spills. These are formatted similar to Material Safety Data Sheets (MSDSs) and include a glossary. More than half of the sheets have also been translated to Spanish.
New Zealand Hazardous Substances and New Organisms (HSNO), Chemical Classification Information Database (CCID)
The CCID details the chemicals classified in accordance with the HSNO regulations and is an implementation of the GHS. The CCID is used by industry to classify formulated products and can be used to formulate less hazardous products by providing the classification information on potential alternative components. The CCID provides chemical identification information, hazard classifications and classification data.
National Institute for Occupational Safety and Health (NIOSH), Control Banding
NIOSH Control Banding is a technique used to assess and manage workplace risks, basing workplace control measures, such as ventilation or engineering controls, on a range or “band” of hazards and exposures. This process capitalizes on the experience of controlling occupational chemical exposures and expanding those solutions to other similar exposure concerns. Control banding is most effective when used with health and safety practices such as chemical substitution.
NIOSH Pocket Guide (NPG) to Chemical Hazards (US NLM)
The NIOSH Pocket Guide is a source of general industrial hygiene information on several hundred chemicals and classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.
Occupational Safety and Health Administration (OSHA), Occupational Chemical Database
This chemical database is maintained by OSHA as a convenient reference for the occupational safety and health community. It compiles information from several government agencies and organizations and includes data on physical properties, occupational safety classifications, exposure guidelines, NIOSH Pocket Guide, and emergency response information, including the DOT Emergency Response Guide. The chemicals are indexed by name and CASRN.
Organisation for Economic Cooperation and Development (OECD), eChemPortal
eChemPortal provides public access to information on properties of chemicals such as physical/chemical properties, ecotoxicity, environmental fate and behavior, and toxicity. It allows simultaneous searching of reports and datasets by chemical name and number and by chemical property. eChemPortal also provides exposures and use information on chemicals. It aggregates several toxicity and ecotoxicity databases worldwide.
Organisation for Economic Cooperation and Development (OECD), Existing Chemicals Database
CDC/NIOSH Occupational Carcinogen List is a list of substances that NIOSH considers to be potential carcinogens that can be found in the workplace. This list may be reevaluated as new data becomes available to change the status of the carcinogen or to adjust the recommended exposure limit (REL).
Organisation for Economic Cooperation and Development (OECD), Existing Chemicals, Screening Information Data Sets (SIDS)
The SIDS program is focused on developing base level test information on approximately 600 poorly characterized international HPV chemicals. The SIDS data are used to screen the chemicals and set priorities for further testing or risk assessment/management activities. The OECD/SIDS test data set includes physico-chemical properties, results of environmental fate testing, results of environmental effects testing, and results of health effects testing.
The goal of OpenTox is to develop an open-source interoperable predictive toxicology framework which may be used as an enabling platform for the creation of predictive toxicology applications. The OpenTox Framework provides tools for the integration of data from various sources (public and confidential), for the generation and validation of computer models for toxic effects, libraries for the development and seamless integration of new algorithms, and scientifically sound validation routines.
Swedish Chemicals Agency (KEMI) Restricted Substances Database of Sweden
The Restricted Substances Database is an aid to rapidly search rules on prohibitions and other restrictions on use in Sweden that apply to individual chemical substances or groups of substances in the Swedish Chemicals Agency's area of activity. The information contained in the database is limited to the specific provisions that apply to individual chemical substances or groups of substances.
Toxicology Data Network (TOXNET)
TOXNET performs searches through a number of toxicological databases, including those run by the National Library of Medicine. These databases cover a wide array of topics, including toxicology, hazardous chemicals, environmental health, and toxic releases.
TOXLINE is a database run through ProQuest and is produced by the U.S. National Library of Medicine. It contains bibliographic citations and abstracts for literature on all areas of toxicology, including chemicals and pharmaceuticals, pesticides, environmental pollutants, and mutagens and teratogens. This database is available through subscription but can be searched through TOXNET.
TOXMAP is a Geographic Information System (GIS) that uses United States maps to help users visually explore data from the USEPA's Toxics Release Inventory (TRI) and Superfund Program. TOXMAP's chemical and environmental health information is taken from TOXNET and PubMed, and from other authoritative sources.
United Nations Environment Programme (UNEP)
UNEP provides a vast array of materials including a Resource Kit on Sustainable Consumption & Production, a Life Cycle Initiative, and reports on various environmental topics. The Resource Efficiency Program also recently launched the Global Sustainable Consumption and Production (SCP) Clearinghouse, which consists of a large collection of materials revolving around SCP.
U.S. EPA, ACToR (DSSTox, ExpoCast, ToxCast and ToxRefDB)*
ACToR (Aggregated Computational Toxicology Resource) is EPA's online warehouse of all publicly available chemical toxicity data and can be used to find all publicly available data about potential chemical risks to human health and the environment. ACToR aggregates data from over 1000 public sources on over 500,000 environmental chemicals searchable by chemical name, other identifiers and by chemical structure.
Guidance on how to use ACTor http://actor.epa.gov/actor/ACToR_ToxRefDB_Help_24Feb2010.pdf
*Note that all the EPA Ofc of R&D Tools have been grouped here under ACTor as they are all linked and can be searched simultaneously.
U.S. EPA, Health and Environmental Research Online (HERO)
The Health and Environmental Research Online (HERO) database provides an easy way to access and influence the scientific literature behind EPA science assessments. The database includes more than 600,000 scientific references and data from the peer-reviewed literature used by EPA to develop its regulations for the following: Integrated Science Assessments (ISA) that feed into the NAAQS review, Provisional Peer Reviewed Toxicity Values (PPRTV) that represent human health toxicity values for the Superfund, and the Integrated Risk Information System (IRIS), a database that supports critical agency policymaking for chemical regulation. These assessments supported by HERO characterize the nature and magnitude of health risks to humans and the ecosystem from pollutants and chemicals in the environment.
U.S. EPA, Integrated Risk Information System (IRIS)
IRIS is a human health assessment program that evaluates quantitative and qualitative information about effects from exposure to environmental contaminants. US EPA’s IRIS database is a compilation of electronic reports on specific substances found in the environment and their potential to cause human health effects.
U.S. EPA, Pollution Prevention and Toxics (OPPT) Chemical Data Access Tool (CDAT)
Compilation of chemical-specific information submitted to EPA under the TSCA. The tool enables search in the following databases:
U.S. CDC/NIOSH, Occupational Carcinogen List
CDC/NIOSH Occupational Carcinogen List is a list of substances that NIOSH considers to be potential carcinogens that can be found in the workplace. This list may be reevaluated as new data becomes available to change the status of the carcinogen or to adjust the recommended exposure limit (REL).
U.S. NIH/National Cancer Institute
The President's Cancer Panel are appointed by the President to monitor the development and execution of activities of the National Cancer Institute. They publish annual reports on cancer research, which include the 2008-2009 report titled Reducing Environmental Cancer Risk: What we can do now.
U.S. Geological Survey (USGS)
The USGS is a federal science organization that provides impartial information on the health of ecosystems and environment, the natural hazards, the natural resources, and the impacts of climate and land-use change. It also examines the resulting factors that affect ecological and human exposure to disease agents. USGS provides scientific information and tools (including maps, imagery, and publications) as a basis for management and policy decision making.
U.S. National Library of Medicine, National Center for Biotechnology Information, PubChem
PubChem is a compilation of three linked databases: PubChem Substance, PubChem Compound, and PubChem BioAssay. It provides information on the biological activities of small molecules and contains a fast chemical structure similarity search tool. It also includes records for individual chemicals with details such as use and manufacturing, pharmacology, environmental and health impacts and toxicity, bioassays, and exposure standards and regulations. It also provides links to PubMed and TOXNET.
U.S. National Library of Medicine, National Center for Biotechnology Information, PubChem Identifier Exchange Service
Within the PubChem Identifier Exchange Service, input identifiers (IDs) are converted into compound IDs, which are called input CIDs. The CIDs that satisfy the condition specified by the selected operation type are retrieved. We called these CIDs, output CIDs. The output CIDs are then converted into the ID type specified by the user and written into a file or Entrez history.
U.S. National Library of Medicine, ChemIDplus
ChemIDplus is a dictionary compiled from over 70 sources containing over 370,000 chemicals including their names, synonyms, and structures. It focuses on chemical properties. It also allows searching by any combination of name, registry number, molecular formula, classification code, locator code, toxicity, physical property, structure, or molecular weight. Toxicity and physical property data are displayed in tables under Basic Information.
World Health Organization (WHO) International Programme on Chemical Safety (IPCS) Concise International Chemical Assessment Documents (CICADs) and Environmental Health Criteria (EHC) Documents
CICADs are similar to EHC documents in providing internationally accepted reviews on the effects on human health and the environment of chemicals or combinations of chemicals. They aim to characterize the hazard and dose-response of exposure to chemicals and to provide examples of exposure estimation and risk characterizations for application at the national or local level.
Washington State, Children’s Safe Products Act (CSPA) Reports
CSPA requires a list of chemicals on which manufacturers must report, called the Reporting List of Chemicals of High Concern to Children. Chemicals on the list are toxic and have either been found in children’s products or have documented presence in human tissue (blood, breast milk, etc.); however, their presence is not necessarily indicative of risk of harm. The manufacturers' reports are searchable by chemical, product code, or company with information about chemical concentrations.
World Health Organization, Health Topics
WHO is the directing and coordinating authority for health within the United Nations system. The WHO Health Topics contain links to WHO projects, initiatives, activities, information products, and contacts, organized by health and development topics.
To address the changes in California based on the new Safer Consumer Product Regulations by CA DTSC, Elara Bioscience created ToxPlatform, a comprehensive, cloud-based toxicology data and analytical service designed to integrate the full spectrum of chemical toxicity resources applicable to human health from chemical exposures. It also provides a list of Candidate Chemicals. The resources are based on a subscription.
The International Chemical Secretariat (ChemSec) Substitute It Now (SIN) List
The SIN list (Substitute It Now) is an NGO driven project identifying Substances of Very High Concern based on the criteria established by REACH. For each of these substances, the database provides information about the uses, hazard traits, biomonitoring data, and its inclusion in certain types of products. The aim of the SIN List is to provide a tool, which companies and other actors can use to substitute hazardous chemicals with safer alternatives ahead of legislation.
Toxipedia is a free toxicology encyclopedia offeringarticles and resources about toxic chemicals (such as pesticides and endocrine disruptors), health conditions, ethical considerations, the history of toxicology, laws and regulation, and more.
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