Chemical Information

Government Links - Chemical Information

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Agency of Toxic Substances & Disease Registry (ATSDR), Toxic Substances Portal Toxicological Profiles 

From CERCLA, ATSDR worked with USEPA to develop a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) and prepare toxicological profiles for each substance included on the priority list of hazardous substances. The toxicological profiles include an examination, summary, and interpretation of available toxicological information and epidemiologic evaluations of a hazardous substance. During the development of toxicological profiles, MRLs are derived when ATSDR determines that reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure to the substance.

Canadian Environmental Protection Act (CEPA) Toxic Substances List

CEPA 1999 includes regulations to protect the environment and human health and establishes strict timelines for managing substances found toxic under the Act, which compose the Toxic Substances List. These substances determined to be "toxic", persistent, bioaccumulative, anthropogenic, and which are not naturally occurring radionuclides or naturally occurring inorganic substances shall be proposed for implementation of virtual elimination. A substance is declared "CEPA-toxic" as a result of a systematic, risk-based assessment.

Canada Domestic Substances List (DSL)

The Canadian DSL search engine is combined with the New Substances Search Engine to provide the name and the list on which the chemical is included. The DSL in particular identifies about 23,000 substances that existed on Canadian commerce whether for manufacturing or import between 1984 and 1986, including quantities of above 100 kg/year. These substances were defined as toxic or capable of becoming toxic by the Canadian Environmental Protection Act (CEPA 1999).

California Department of Toxic Substances Control

This link provides access to the user portion of the Toxic Information Clearinghouse. Users can search for chemicals and associated hazard traits and end points. The chemical search searches by chemical name or CASRN number. The advanced search is intended for searching by hazard trait or end point although it will search the authoritative sources by any key words.

Chemical Risk Information Platform (CHRIP)

CHRIP is a database provided free of charge and managed by the Japanese National Institute and Technology and Evaluation. It provides comprehensive information on risk assessments (including toxicity, hazards, chemical/physical properties, exposures, etc.) and Japanese and international laws and regulations of chemical substances. It also includes information on biodegradation and bioconcentration of existing chemical substances. These substances can be searched by entering the number or name, by category lists, or by structure.

Consumer Products Safety Commission (CPSC)

The CPSC aims to protect consumers and families from products that pose a fire, electrical, chemical, or mechanical hazard. It provides information on various consumer products, recall lawsuits, safety education, regulations and legislation, and research and statistics on injuries related to the products. CPSC also allows for online reporting of unsafe products.

Data Bank of Environmental Properties of Chemicals (EnviChem)

The EnviChem database consists of toxicity information on substances in relation to different species, especially aquatic organisms, together with information on the persistence and accumulation of these substances in the environment. The information is mainly compiled from scientific literature, handbooks and databases in the field of ecotoxicology. The database also contains practical data on chemical substances for that purpose.

European Bioinformatics Institute (EBI), Chemical Entities of Biological Interest (ChEBI)

ChEBI is a database of molecular entities focused on small chemical compounds. These molecular entities can be either products of nature or synthetic products used to intervene in the processes of living organisms. It also includes classification, nomenclature, and ontology. A number of other sources, such as ChEMBL, PDBeChem, and KEGG COMPOUND are accessible through ChEBI.

European Bioinformatics Institute (EBI), ChEMBL

ChEMBL is a database of bioactive drug-like small molecules focusing on chemical properties. It contains 2-D structures, calculated properties (e.g. logP, Molecular Weight, Lipinski Parameters, etc.), and abstracted bioactivities (e.g. binding constants, pharmacology and ADMET data).

European Chemicals Agency (ECHA) Information on Chemicals

The ECHA Information on Chemicals section serves as a gateway to ECHA's public databases on chemical substances, which contain a large range of information including chemical/physical properties, environmental impact, uses, toxicological data, etc. It also includes information on registration dossiers for substances where a testing proposal has been made, together with information related to the transitional arrangements from the previous chemicals legislation.

European Chemicals Agency (ECHA), Candidate List of Substances of Very High Concern

The ECHA Candidate List of Substance of Very High Concern contains information on each of the substances that are considered very harmful to human health and/or the environment by ECHA. For each substance, it includes chemical properties and data from hazard assessments, justifying its inclusion on the list.

European Chemicals Agency’s Dissemination Portal

This list serves as the European Chemicals Agency’s Dissemination portal with information on chemical substances registered under REACH. It contains all of the information constantly being submitted to and processed by ECHA due to the deadlines of the REACH regulations.

European Inventory of Existing Commercial Chemical Substances (EINECS)

Like EC-ESIS, EINECS is a database containing information and data regarding various chemicals in the European chemical inventory. It provides some hazard and trade data as well as any EU Commission decisions. It was compiled in 1990 and is occasionally updated. It is accessible through EC-ESIS.

Finnish Institute of Occupational Health (FIOH)

FIOH is a research and specialist organization in the field of occupational health and safety. It examines various health and safety hazards and produce tools to improve occupational health and reduce risks.

Globally Harmonized System (GHS)

The GHS is a classification scheme for chemicals to consistently communicate hazard information about chemicals world-wide. The GHS includes harmonized criteria for classifying substances and mixtures according to their health, environmental and physical hazards, as well as harmonized requirements for labeling and safety data communication.

Information on Hazardous Chemicals and Occupational Diseases (Haz-Map)

Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the health effects of exposure to chemicals and biologicals at work. Haz-Map links jobs and hazardous tasks with occupational diseases and their symptoms. The main links in Haz-Map are between chemicals and occupational diseases, in which causality has been established based on current scientific evidence.

International Agency for Research on Cancer (IARC)

IARC promotes international collaboration in cancer research and developed criteria to evaluate carcinogenic risks to humans and publishes monographs describing these evaluations. It also maintains a summary list of agents classified by IARC monographs, but recommends consulting the monograph itself for full interpretation of the classification.

International Programme on Chemical Safety (IPCS), Chemical Safety Information from Intergovernmental Organizations (INCHEM)

IPCS INCHEM is an invaluable tool that focuses on safety and the sound management for a wide range of commercial chemicals. It consolidates current, internationally peer-reviewed chemical safety-related publications and database records from international bodies, for public access.

International Union of Pure and Applied Chemistry (IUPAC), International Chemical Identifier (InChI)

InChI is a chemical descriptor that is also human-readable and is an excellent way to encode molecular structures as unique text strings. They are not very useful for large data sets and are only applicable to molecular pure compounds. Also, chemical mixtures and covalent network solids or minerals are not supported.

National Toxicology Program Office of Health Assessment and Translation (OHAT)

The NTP OHAT conducts technical assessments focused on understanding the potential for adverse effects on human health by agents, substances, mixtures, or exposure circumstances. These evaluations can lead to NTP opinions on whether these substances may be of concern given what is known about current human exposure levels. OHAT produces NTP Monographs, state-of-the-science workshop reports, or peer-reviewed journal publications based on their evaluations.

National Toxicology Program, Report on Carcinogens (RoC)

The RoC is a congressionally mandated, science-based, public health report that identifies agents, substances, mixtures, or exposures in our environment that may potentially put people in the United States at increased risk for cancer. For every substance listed, the RoC contains a profile including cancer studies (mechanism, human, animal), potential sources of exposure, and current federal regulations to limit exposures.

National Institute for Occupational Safety and Health (NIOSH), Control Banding

NIOSH Control Banding is a technique used to assess and manage workplace risks, basing workplace control measures, such as ventilation or engineering controls, on a range or “band” of hazards and exposures. This process capitalizes on the experience of controlling occupational chemical exposures and expanding those solutions to other similar exposure concerns. Control banding is most effective when used with health and safety practices such as chemical substitution.

New Jersey, Right to Know Hazardous Substance Fact Sheets

The Hazardous Substance Fact Sheets are prepared on pure substances and contain information on health hazards, exposure limits, personal protective equipment, proper handling, first aid, and emergency procedures for fires and spills. These are formatted similar to Material Safety Data Sheets (MSDSs) and include a glossary. More than half of the sheets have also been translated to Spanish.

National Institute for Occupational Safety and Health (NIOSH), Control Banding

NIOSH Control Banding is a technique used to assess and manage workplace risks, basing workplace control measures, such as ventilation or engineering controls, on a range or “band” of hazards and exposures. This process capitalizes on the experience of controlling occupational chemical exposures and expanding those solutions to other similar exposure concerns. Control banding is most effective when used with health and safety practices such as chemical substitution.

NIOSH, Pocket Guide (NPG) to Chemical Hazards

The NIOSH Pocket Guide is a source of general industrial hygiene information on several hundred chemicals and classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

NIH/National Cancer Institute and Computer-Aid Drug Design (CADD) Group, Chemical Identifier Resolver

The Chemical Identifier Resolver works as a resolver for different chemical structure identifiers and allows one to convert a given structure identifier into another representation or structure identifier. It can help you identify and find the chemical structure if you have an identifier such as an InChIKey. It's still in beta testing.

National Oceanic and Atmospheric Administration (NOAA), CAMEO

CAMEO Database of Hazardous Materials:

CAMEO is a system of software applications used widely to plan for and respond to chemical emergencies. It is one of the tools developed by EPA's Chemical Emergency Preparedness and Prevention Office (CEPPO), U.S. Coast Guard and the National Oceanic and Atmospheric Administration Office of Response and Restoration (NOAA), to assist front-line chemical emergency planners and responders. They can use CAMEO to access, store, and evaluate information critical for developing emergency plans. The online version is maintained by NOAA's Office of Response and Restoration.

Organisation for Economic Cooperation and Development (OECD), eChemPortal

eChemPortal provides public access to information on properties of chemicals such as physical/chemical properties, ecotoxicity, environmental fate and behavior, and toxicity. It allows simultaneous searching of reports and datasets by chemical name and number and by chemical property. eChemPortal also provides exposures and use information on chemicals. It aggregates several toxicity and ecotoxicity databases worldwide.

Organisation for Economic Cooperation and Development (OECD), Existing Chemicals Database

The OECD Existing Chemicals Database tracks all chemicals in the OECD cooperative Chemicals Assessment Programme, particularly high production volume (HPV). OECD publishes publicly-available assessment reports for international HPV chemicals, which are indexed by CAS numbers and chemical names and include existing information on the chemical identity, physical characteristics, sources and levels of exposure, environmental fate and pathways of exposure, and toxicological and ecotoxicological data.

Organisation for Economic Cooperation and Development (OECD) Existing Chemicals, Screening Information Data Sets (SIDS)

The SIDS program is focused on developing base level test information on approximately 600 poorly characterized international HPV chemicals. The SIDS data are used to screen the chemicals and set priorities for further testing or risk assessment/management activities. The OECD/SIDS test data set includes physico-chemical properties, results of environmental fate testing, results of environmental effects testing, and results of health effects testing.

Occupational Safety and Health Administration (OSHA), Occupational Chemical Database

This chemical database is maintained by OSHA as a convenient reference for the occupational safety and health community. It compiles information from several government agencies and organizations and includes data on physical properties, occupational safety classifications, exposure guidelines, NIOSH Pocket Guide, and emergency response information, including the DOT Emergency Response Guide. The chemicals are indexed by name and CASRN.

OSHA, Transitioning to Safer Chemicals: A Toolkit for Employers and Workers

OSHA has developed this step-by-step toolkit to provide employers and workers with information, methods, tools, and guidance on using informed substitution in the workplace.

Royal Society of Chemistry, Cambridge (UK), ChemSpider

ChemSpider is a free chemical structure database providing text and structure search access to over 28 million structures from hundreds of data sources. It allows for searches by properties and associated information about the chemical. Additionally, it has services for identifier exchange and property prediction.

Swedish Chemicals Agency (KEMI) Restricted Substances Database of Sweden

The Restricted Substances Database is an aid to rapidly search rules on prohibitions and other restrictions on use in Sweden that apply to individual chemical substances or groups of substances in the Swedish Chemicals Agency's area of activity. The information contained in the database is limited to the specific provisions that apply to individual chemical substances or groups of substances.

United Nations Environment Programme (UNEP)

UNEP provides a vast array of materials including a Resource Kit on Sustainable Consumption & Production, a Life Cycle Initiative, and reports on various environmental topics. The Resource Efficiency Program also recently launched the Global Sustainable Consumption and Production (SCP) Clearinghouse, which consists of a large collection of materials revolving around SCP.

U.S. National Library of Medicine, ChemIDplus

ChemIDplus is a dictionary compiled from over 70 sources containing over 370,000 chemicals including their names, synonyms, and structures. It focuses on chemical properties. It also allows searching by any combination of name, registry number, molecular formula, classification code, locator code, toxicity, physical property, structure, or molecular weight. Toxicity and physical property data are displayed in tables under Basic Information.

U.S. EPA, ACToR (DSSTox, ExpoCast, ToxCast and ToxRefDB)*

ACToR (Aggregated Computational Toxicology Resource) is EPA's online warehouse of all publicly available chemical toxicity data and can be used to find all publicly available data about potential chemical risks to human health and the environment. ACToR aggregates data from over 1,000 public sources on over 500,000 environmental chemicals searchable by chemical name, other identifiers and by chemical structure.

  • Includes chemical structure, physico-chemical values, in vitro assay data and in vivo toxicology data.
  • Includes, but not limited to, high and medium production volume industrial chemicals, pesticides (active and inert ingredients), and potential ground and drinking water contaminants.

Guidance on how to use ACTor

*Note that all the EPA Ofc of R&D Tools have been grouped here under ACTor as they are all linked and can be searched simultaneously.

U.S. EPA, Chem View

The ChemView web tool displays key health and safety data that has been submitted to or generated by U.S. EPA's Office of Chemical Safety and Pollution Prevention. ChemView currently provides information on 1500 chemicals. The tool is a key step in EPA’s commitment to transparency of environmental data. Chemical info is displayed in an online format that allows comparison of chemicals by use and by health or environmental effects. The search tool combines available Toxic Substances Control Act (TSCA) information and provides streamlined access to U.S. EPA assessments, hazard characterizations, and information on safer chemical ingredients. Additionally, the new web tool allows searches by chemical name or Chemical Abstracts Service (CAS) number, use, hazard effect, or regulatory action. It has the flexibility to create tailored views of the information on individual chemicals or compare multiple chemicals sorted by use, hazard effect or other criteria. The new portal will also link to information on manufacturing, processing, use, and release data reported under the Chemical Data Reporting Rule, and the Toxics Release Inventory.

U.S. EPA, Integrated Risk Information System (IRIS)

U.S. EPA's Integrated Risk Information System (IRIS) is a human health assessment program that evaluates quantitative and qualitative information about effects from exposure to environmental contaminants. IRIS provides information on cancer and non-cancer health effects on 550 chemical substances including human health effects that may result from exposure to these substances. IRIS is a compilation of electronic reports on specific substances found in the environment and their potential to cause human health effects. U.S. EPA’s National Center for Environmental Assessment (NCEA) within the Office of Research and Development (ORD) prepares and maintains IRIS.

U.S. EPA, Use Cluster Scoring System (UCSS)

EPA UCSS identifies and screens clusters of chemicals used to perform particular tasks (use clusters). A use cluster is a set of chemicals that may be substituted for each other for specific tasks. UCSS identifies cluster of potential concern and ranks chemicals using human health, environmental hazard and exposure data. Users may use the system to compare the toxicity of similar chemicals used to perform a particular task.

U.S. EPA, Chemical Data Access Tool (CDAT)

EPA Pollution Prevention and Toxics (OPPT) Chemical Data Access Tool (CDAT). Compilation of chemical-specific information submitted to EPA under the TSCA. The tool enables search in the following databases: 

  • CDR - This database includes non-confidential information on the manufacture (including import), process and use of chemicals reported under the Chemical Data Reporting (CDR) rule.  eDoc - The eDoc database includes a broad range of health and safety information reported by industry under TSCA Sections 4,5, 8(d), and 8(e).
  • TSCATS - The TSCA Test Submissions (TSCATS) database is an online index to unpublished, nonconfidential studies covering chemical testing results and adverse effects of chemicals on health and ecological systems. 
  • HPVIS - The High Production Volume Information System (HPVIS) is a database that provides access to health and environmental effects information obtained through the High Production Volume (HPV) Challenge. 
  • Declassified CBI - This database includes health and safety studies and other information submitted to EPA in which chemical identities have been declassified. The declassified documents can be found by searching (CDAT).

U.S. EPA, Safer Chemical Ingredients for Use in Design for the Environment-Labeled Products

This list of safer chemical ingredients is arranged by functional-use class and will assist product manufacturers in identifying chemicals that the DfE program has already evaluated and identified as safer.

U.S. EPA, Simplified Molecular-Input Line-Entry System (SMILES)

SMILES is a line notation specification used for describing the structure of chemical molecules using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules. It has similar limitations to InCHI.

U.S. EPA, Substance Registry System (SRS)

The Substance Registry System (SRS) provides information on substances (e.g., chemicals, biological organisms) and how they are represented in the Environmental Protection Agency (EPA) regulations and information systems.

U.S. EPA, Ecological Structure Activity Relationships (ECOSAR)

ECOSAR estimates a chemical's acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms such as fish, aquatic invertebrates, and aquatic plants using structure-activity relationships (SARs) to predict the aquatic toxicity of untested chemicals based on their structural similarity to chemicals for which aquatic studies are available. The toxicity data used to build the SARs are collected from publicly available experimental studies and confidential submissions provided to the U.S. EPA New Chemicals Program. The SARs in ECOSAR express correlations between a compound's physicochemical properties and its toxicity within specific chemical classes. A user provides information about a chemical’s structure and the octanol/water partition coefficient to operate the model. The model is applicable to organic chemicals with a molecular weight of 1,000. ECOSAR is included as part of U.S. EPA’s EPI Suite™ but that version is not as up-to-date as the stand-alone version.

U.S. National Library of Medicine, National Center for Biotechnology Information, PubChem

PubChem is a compilation of three linked databases: PubChem Substance, PubChem Compound, and PubChem BioAssay. It provides information on the biological activities of small molecules and contains a fast chemical structure similarity search tool. It also includes records for individual chemicals with details such as use and manufacturing, pharmacology, environmental and health impacts and toxicity, bioassays, and exposure standards and regulations. It also provides links to PubMed and TOXNET.

U.S. National Library of Medicine, National Center for Biotechnology Information, PubChem Identifier Exchange Service

Within the PubChem Identifier Exchange Service, input identifiers (IDs) are converted into compound IDs, which are called input CIDs. The CIDs that satisfy the condition specified by the selected operation type are retrieved. We called these CIDs, output CIDs. The output CIDs are then converted into the ID type specified by the user and written into a file or Entrez history.

Washington State, Children’s Safe Products Act (CSPA) Reports
CSPA Search Database:

CSPA requires a list of chemicals on which manufacturers must report, called the Reporting List of Chemicals of High Concern to Children. Chemicals on the list are toxic and have either been found in children’s products or have documented presence in human tissue (blood, breast milk, etc.); however, their presence is not necessarily indicative of risk of harm. The manufacturers' reports are searchable by chemical, product code, or company with information about chemical concentrations.

Washington State Department of Ecology, Persistent, Bioaccumulative Toxics (PBT) Initiative

The PBT Initiative aims to reduce and phase-out the use, release, and exposure to PBTs in Washington in order to reduce and eliminate threats to human health and the environment. The PBT List is published and Chemical Action Plans (CAPs) are being created for each substance currently on the list.

World Health Organization (WHO) International Programme on Chemical Safety (IPCS) Concise International Chemical Assessment Documents (CICADs) and Environmental Health Criteria (EHC) Documents

CICADs are similar to EHC documents in providing internationally accepted reviews on the effects on human health and the environment of chemicals or combinations of chemicals. They aim to characterize the hazard and dose-response of exposure to chemicals and to provide examples of exposure estimation and risk characterizations for application at the national or local level.

World Health Organization Health Topics

WHO is the directing and coordinating authority for health within the United Nations system. The WHO Health Topics contain links to WHO projects, initiatives, activities, information products, and contacts, organized by health and development topics.

Private Sector Links - Chemical Information

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Chemical Abstracts Service Registry Numbers (CASRN)

CASRN is a collection of publicly disclosed chemical substance information covering substances identified from scientific literature from 1957 to present, with some from the early 1900s. CAS numbers are unique and specific to only one substance. The registry of chemicals can be searched using SciFinder, STN databases, CAS publications, and other publications.

Elara Bioscience

To address the changes in California based on the new Safer Consumer Product Regulations by CA DTSC, Elara Bioscience created ToxPlatform, a comprehensive, cloud-based toxicology data and analytical service designed to integrate the full spectrum of chemical toxicity resources applicable to human health from chemical exposures. It also provides a list of Candidate Chemicals. The resources are based on a subscription.

Interactive Learning Paradigms, Inc. (ILPI), The MSDS FAQ

Main Page:

The MSDS FAQ provides diverse information about material safety data sheets (MSDSs) and links to many sites that include MSDSs.

Risk Assessment for Contaminated Sites in New Zealand

This web site aims to guide environmental managers through a framework for assessing contaminated sites and to provide information resources relevant to New Zealand assessors, auditors or reviewers. It is specifically aimed at the risk assessment of superfund sites in New Zealand. This is a collaborative venture between a number of organizations. It also provides reviews on various risk assessment tools.

Non Governmental Organization Links - Chemical Information

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Environmental Working Group (EWG), Skin Deep

Skin Deep is a electronic product database that contains ingredients in 66,402 products. EWG obtained detailed information on these products from online retailers, manufacturers, product packaging, and, to a lesser extent, through other methods described below. In most cases, the information obtained includes a brand name, product name, directions for use, warnings, ingredients, package/advertising text, and indications (cosmeceuticals).


GoodGuide provides information on health, environmental, and social impacts of consumer products. It uses a vast amount of data linking chemicals to products but the data are not exposed for public use other than through the website.

GoodGuide Scorecard

Scorecard is the resource for information about pollution problems and toxic chemicals. It provides information about the pollution problems in local communities and the responsible parties. It also allows users to see which geographic areas and companies have the worst pollution records as well as identify which racial/ethnic and income groups bear more than their share of environmental burdens. It utilizes USEPA TRI data with information on the potential health hazards of toxic chemicals to examine pollution.

Health Product Declaration Collaborative, Health Product Declaration Open Standard

The Health Product Declaration Open Standard is a standard format that systematizes reporting language to enable transparent disclosure of information regarding building product content and associated health information, by defining the critical information that is needed by building designers, specifiers, owners and users. This was developed by the Healthy Building Network and BuildingGreen.

Academic Links - Chemical Information

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Carcinogen Exposure (CAREX) Canada

CAREX Canada is a national surveillance project that estimates the number of Canadians exposed to substances associated with cancer in workplace and community environments. These estimates provide support for targeting exposure reduction strategies and cancer prevention programs. CAREX Canada also creates chemical profiles for these substances containing regulations and guidelines, exposure data, properties, and uses in a Canadian Workplace Exposure Database. It provides mapping tools to examine environmental and occupational exposures and related sources.

Kyoto Encyclopedia of Genes and Genomics (KEGG), Compound Database

KEGG COMPOUND is a collection of small molecules, biopolymers, and other chemical substances that are relevant to biological systems. Each entry is identified by the C number, such as C00047 for L-lysine, and contains chemical structure, reactions, pathways, and other associated information, as well as links to other KEGG and outside databases.

North Carolina State University & Mount Desert Island Biological Laboratory, Comparative Toxicogenomics Database (CTD)

CTD promotes understanding about the effects of environmental chemicals on human health by integrating data from curated scientific literature to describe chemical interactions with genes and proteins, and associations between diseases and chemicals, and diseases and genes/proteins. CTD is working to enhance the capacity to identify environment–disease connections by developing an Exposure Ontology (ExO) that will be used to curate and present exposure data.